3105302-84-6
3105302-84-6
Chemical Structure
D-TLKIVWC
- CAS No.: 3105302-84-6
- Formula:C41H67N9O9S
- Molecular Weight:862.09
InChIKey: SSMCLSCMIXQYBK-ZZZXQBPGSA-N
SMILES: C[C@H](O)[C@@H](N)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(N[C@H]([C@H](C)CC)C(N[C@H](C(C)C)C(N[C@@H](C(N[C@H](CS)C(O)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)=O
Biological Activity: D-TLKIVWC is a Tau depolymerizing agent (IC50 = 12.1 μM). D-TLKIVWC depolymerizes Tau into benign, seed-incompetent fragments. D-TLKIVWC rescues behavioral deficits in mouse models and protects neurons from Tau-induced toxicity. D-TLKIVWC can be used for research on Alzheimer's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
D-TLKIVWC | D-TLKIVWC is a Tau depolymerizing agent (IC50 = 12.1 μM). D-TLKIVWC depolymerizes Tau into benign, seed-incompetent fragments. D-TLKIVWC rescues behavioral deficits in mouse models and protects neurons from Tau-induced toxicity. D-TLKIVWC can be used for research on Alzheimer's disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Hou K, et al. How short peptides disassemble tau fibrils in Alzheimer's disease. Nature. 2025 Aug;644(8078):1020-1027. [Content Brief]
- [2]. Hou K, et al. D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Sci Adv. 2024 May 3;10(18):eadl2991.
- [3]. Eisenberg D, et al. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Res Sq [Preprint]. 2024 May 8:rs.3.rs-4152095.
