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Cat. No.: HY-P11593

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D-TLKIVWC

D-TLKIVWC is a tau fibril disaggregator. D-TLKIVWC has low immunogenicity and anti-degradation properties. D-TLKIVWC disrupts intermolecular hydrogen bonds of tau via a stress-release mechanism. D-TLKIVWC can be used in the research of amyloid diseases such as Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 3105302-84-6
Formula: C₄₁H₆₇N₉O₉S
Molecular Weight:862.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D-TLKIVWC Chemical Structure

CAS No.: 3105302-84-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

D-TLKIVWC (500 μM; 48 h) disassembles AD-tau fibrils and recombinant tau K18+ fibrils in vitro without requiring disulfide bond formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3105302-84-6
Molecular Weight 862.09
Formula C₄₁H₆₇N₉O₉S
Sequence

d-{Thr-Leu-Lys-Ile-Val-Trp-Cys}
Sequence Shortening

d-{TLKIVWC}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hou K, et al. How short peptides disassemble tau fibrils in Alzheimer's disease. Nature. 2025;644(8078):1020-1027. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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