3122-01-8
Chemical Structure
Thiazesim hydrochloride
- CAS No.: 3122-01-8
- Formula:C19H23ClN2OS
- Molecular Weight:362.92
IUPAC Name: 5-(2-(dimethylamino)ethyl)-2-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one hydrochloride
InChIKey: IUZXQGCIJLIGLS-UHFFFAOYSA-N
SMILES: O=C1N(CCN(C)C)C2=C(SC(C1)C3=CC=CC=C3)C=CC=C2.Cl
Biological Activity: Thiazesim hydrochloride is a CNS-penetrant GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim hydrochloride depresses amygdala output, disrupts conditioned avoidance response in rats. Thiazesim hydrochloride can be used for the research of depression and epilepsy[1][2][3][4][5].
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Thiazesim hydrochloride | Thiazesim hydrochloride is a CNS-penetrant GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim hydrochloride depresses amygdala output, disrupts conditioned avoidance response in rats. Thiazesim hydrochloride can be used for the research of depression and epilepsy. | |||||||||||||||||||||
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- [1]. Barratt ES. The effects of thiazesim, LSD-25, and bilateral lesions of the amygdalae on the release of a suppressed response. Recent Adv Biol Psychiatry. 1966;9:229-40. [Content Brief]
- [2]. Bell R, et al. The effects of two "anti-aggressive" compounds, an indenopyridine and a benzothiazepin, on shock-induced defensive fighting in rats. Prog Neuropsychopharmacol. 1979;3(4):399-402. [Content Brief]
- [3]. Dreyfuss J, et al. Metabolism of Thiazesim, 5-(2-Dimethylaminoethyl)-2,3-Dihydro-2-Phenyl-1,5-Benzothiazepin-4(5H)-One, in the Rat In Vivo and In Vitro. Journal of Pharmaceutical Sciences 1968, 57 (9), 1505-1511.
- [4]. Marques, et al. Conditioned avoidance deficits induced in rats by an amygdala depressant, Thiazesim HCl.
- [5]. Geyer HM 3rd, et al. Effects of a tranquilizer and two antidepressants on learned and unlearned behaviors. J Pharm Sci. 1970 Jul;59(7):964-8. [Content Brief]
Keywords
