31232-26-5
Chemical Structure
Danitracen
Synonym(s): NSC 170955; WA 335
- CAS No.: 31232-26-5
- Formula:C20H21NO
- Molecular Weight:291.39
IUPAC Name: 10-(1-methylpiperidin-4-ylidene)-9,10-dihydroanthracen-9-ol
InChIKey: HLBRHTFSMMEHPK-UHFFFAOYSA-N
SMILES: OC1C2=C(C=CC=C2)/C(C3=CC=CC=C13)=C4CCN(C)CC/4
Biological Activity: Danitracen (NSC 170955) is an orally active, CNS penetrant serotonin antagonist with antidepressant activity. Danitracen reduces serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. Danitracen exhibits anticataleptic effects in rat catalepsy models. Danitracen can be used for catalepsy and depression research[1][2][3].
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Danitracen | Danitracen (NSC 170955) is an orally active, CNS penetrant serotonin antagonist with antidepressant activity. Danitracen reduces serotonin levels in the cerebrum, cerebellum, medulla and the whole brain. Danitracen exhibits anticataleptic effects in rat catalepsy models. Danitracen can be used for catalepsy and depression research. | |||||||||||||||||||||
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- [1]. Maj J, et al. Influence of WA-335, a factor which blocks serotonin receptors, on neuroleptic-induced catalepsy. Arch Immunol Ther Exp (Warsz). 1976;24(2):197-203. [Content Brief]
- [2]. Kaumeier S, et al. WA 335 (danitracen): a preliminary evaluation of a potential antidepressant compound. A comparative double-blind study with WA 335 and amitriptyline in the treatment of depressive patients. Curr Ther Res Clin Exp. 1977 Jan;21(1):108-13. [Content Brief]
Keywords
