329706-62-9
Chemical Structure
AG6033
- CAS No.: 329706-62-9
- Formula:C30H23N5O4
- Molecular Weight:517.53
IUPAC Name: (E)-7-(3-(aminomethyl-d2)-4-(methoxyimino)pyrrolidin-1-yl-4-13C)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
InChIKey: DUXIDJFLWMQRQM-KGGMANCPSA-N
SMILES: O=C(N/N=C1C(N(CC(NC2=CC=CC=C2)=O)C3=C\1C=CC=C3)=O)C4=CC=CC(NC(C5=CC=CC=C5)=O)=C4
Biological Activity: AG6033 is a CRBN-dependent molecular glue degrader targeting GSPT1 (DC50 of 2.5 μM) and IKZF1. AG6033 induces degradation of GSPT1 via π-π stacking and hydrogen bonding with CRBN in a partially CRBN-dependent manner, decreases IKZF1 levels, and promotes degradation of CRBN substrates. AG6033 induces apoptosis in lung adenocarcinoma cells. AG6033 can be used for the research of lung cancer[1][2].
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AG6033 | AG6033 is a CRBN-dependent molecular glue degrader targeting GSPT1 (DC50 of 2.5 μM) and IKZF1. AG6033 induces degradation of GSPT1 via π-π stacking and hydrogen bonding with CRBN in a partially CRBN-dependent manner, decreases IKZF1 levels, and promotes degradation of CRBN substrates. AG6033 induces apoptosis in lung adenocarcinoma cells. AG6033 can be used for the research of lung cancer. | |||||||||||||||||||||
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References
- [1]. Cheng B, et al. Research Progress in Targeting GSPT1: Molecular Glues, Bifunctional Degraders, and Antibody-Enabled Molecular Glues for Cancer Therapy. Journal of medicinal chemistry. 2025 Jul 10;68(13):13169-13185.
- [2]. Xiong F, et al. Discovery of potential novel CRBN modulators by virtual screening and bioassay. European journal of medicinal chemistry. 2022 Jun 05;236:114355. [Content Brief]
