331948-99-3
331948-99-3
Chemical Structure
MEPB
- CAS No.: 331948-99-3
- Formula:C24H24N2O2S
- Molecular Weight:404.52
IUPAC Name: 2-((2-phenoxyethyl)thio)-1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]imidazole
InChIKey: PNCBJXVNIRRHJP-UHFFFAOYSA-N
SMILES: CC1=CC=C(OCCN2C3=CC=CC=C3N=C2SCCOC4=CC=CC=C4)C=C1
Biological Activity: MEPB is a modulator of AF-2 of the androgen receptor. MEPB increases co-repressor binding of AR. MEPB can bind to the BF3 pocket of AR specifically, thereby modulating the binding of co-regulators to the AF2 domain. MEPB alleviates degeneration in spinal bulbar muscular atrophy mouse model[1].
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MEPB | MEPB is a modulator of AF-2 of the androgen receptor. MEPB increases co-repressor binding of AR. MEPB can bind to the BF3 pocket of AR specifically, thereby modulating the binding of co-regulators to the AF2 domain. MEPB alleviates degeneration in spinal bulbar muscular atrophy mouse model. | |||||||||||||||||||||
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