345989-24-4
345989-24-4
Chemical Structure
MIND4-17
- CAS No.: 345989-24-4
- Formula:C20H15N5O3S
- Molecular Weight:405.43
IUPAC Name: 5-nitro-2-((5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)pyridine
InChIKey: OZUBDKIROJPQGE-UHFFFAOYSA-N
SMILES: O=[N+](C1=CN=C(C=C1)SC2=NN=C(COC3=CC=CC=C3)N2C4=CC=CC=C4)[O-]
Biological Activity: MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MIND4-17 | 99.05% | MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.69
HY-117993MIND4 -
Similarity Score 0.65
HY-147233MIND4-19 -
Similarity Score 0.56
HY-136466A2ti-2 -
Similarity Score 0.53
HY-181985Insecticidal agent 30 -
Similarity Score 0.51
HY-147370HIV-1 inhibitor-46 -
Similarity Score 0.50
HY-136465A2ti-1 -
Similarity Score 0.49
HY-15713NMS-873 -
Similarity Score 0.49
HY-402309IGF-1R modulator 1 -
Similarity Score 0.49
HY-174370MePT-S-N-Pme -
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References
- [1]. Luisa Quinti, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chem Biol. 2016 Jul 21;23(7):849-861. [Content Brief]
- [2]. Nan Chen, et al. The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury. J Cell Physiol. 2020 Oct;235(10):7204-7213. [Content Brief]
