35094-45-2
Chemical Structure
ADP-β-S
Synonym(s): Adenosine 5'-(β-thiodiphosphate)
- CAS No.: 35094-45-2
- Formula:C10H15N5O9P2S
- Molecular Weight:443.27
InChIKey: HCIKUKNAJRJFOW-KQYNXXCUSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(O)(OP(S)(O)=O)=O)O[C@H]1N2C3=NC=NC(N)=C3N=C2
Biological Activity: ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S can be used in the research of diseases such as inflammation and diabetes[1][2].
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ADP-β-S | ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S can be used in the research of diseases such as inflammation and diabetes. | |||||||||||||||||||||
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References
- [1]. Suzuki T, et al. Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. Eur J Immunol. 2020;50(2):205-219. [Content Brief]
- [2]. Bertrand G, et al. Adenosine-5'-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas. Br J Pharmacol. 1991;102(3):627-630. [Content Brief]
