354812-16-1
354812-16-1
Chemical Structure
AA43279
- CAS No.: 354812-16-1
- Formula:C12H12N2O2S
- Molecular Weight:248.31
IUPAC Name: 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
InChIKey: OEUITKOCUWEFOB-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)C=C(C2=CC=C(OC)C=C2)S1)N
Biological Activity: AA43279 is an orally effective, blood-brain barrier-penetrant Nav1.1 voltage-gated sodium channel activator with an EC50 of 9.5 μM in HEK-293 cells. AA43279 inhibits fast inactivation and enhances sodium conductance. AA43279 can be used in research on schizophrenia and Dravet syndrome[1][2][3][4][5].
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AA43279 | 98.00% | AA43279 is an orally effective, blood-brain barrier-penetrant Nav1.1 voltage-gated sodium channel activator with an EC50 of 9.5 μM in HEK-293 cells. AA43279 inhibits fast inactivation and enhances sodium conductance. AA43279 can be used in research on schizophrenia and Dravet syndrome. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-115743TAK1-IN-3 -
Similarity Score 0.68
HY-112481IKK2-IN-5 -
Similarity Score 0.63
HY-W773487FtsZ-IN-10 -
Similarity Score 0.61
HY-W5869885-(4-Carboxyphenyl)thiophene-2-carboxylic acid -
Similarity Score 0.59
HY-W0977654,4'-Dimethoxy-1,1'-biphenyl -
Similarity Score 0.59
HY-116204SKLB70326 -
Similarity Score 0.58
HY-115887R110 -
Similarity Score 0.58
HY-W677684Nurr1 agonist 2 -
Similarity Score 0.57
HY-112456IKK2-IN-4 -
Explore the MedChemAI to find more analogs
References
- [1]. Botella H. Molecular Mapping of the Binding Sites of a Nav1. 1 Activator.
- [2]. Weuring WJ, et al. NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome. PloS one. 2020;15(3):e0219106. [Content Brief]
- [3]. Frederiksen K, et al. A small molecule activator of Nav1. 1 channels increases fast‐spiking interneuron excitability and GABAergic transmission in vitro and has anti‐convulsive effects in vivo. European Journal of Neuroscience. 2017 Aug;46(3):1887-96. [Content Brief]
- [4]. Whyte-Fagundes PA, et al. Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish model. Brain Communications. 2024;6(3):fcae135.
- [5]. Chamberland S, et al. Cannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition. bioRxiv. 2025 Aug 26.
