AA43279
Based on 1 Customer Validation
AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 354812-16-1
- Formula: C12H12N2O2S
- Molecular Weight:248.31
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
|
Nav1.1 9.5 μM (IC50) |
Nav1.6 11.6 μM (IC50) |
Nav1.5 14.4 μM (IC50) |
Nav1.2 22.8 μM (IC50) |
Chemical Information
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CAS No. 354812-16-1
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Appearance Solid
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Molecular Weight 248.31
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Formula C12H12N2O2S
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Color Light yellow to light brown
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SMILES
O=C(C1=C(N)C=C(C2=CC=C(OC)C=C2)S1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 6.67 mg/mL (26.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0272 mL | 20.1361 mL | 40.2722 mL | 100.6806 mL |
| 5 mM | 0.8054 mL | 4.0272 mL | 8.0544 mL | 20.1361 mL | |
| 10 mM | 0.4027 mL | 2.0136 mL | 4.0272 mL | 10.0681 mL | |
| 15 mM | 0.2685 mL | 1.3424 mL | 2.6848 mL | 6.7120 mL | |
| 20 mM | 0.2014 mL | 1.0068 mL | 2.0136 mL | 5.0340 mL | |
| 25 mM | 0.1611 mL | 0.8054 mL | 1.6109 mL | 4.0272 mL |
AA43279 Related Classifications
HY-125928 Related Classifications
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