3637-10-3
Chemical Structure
TEMPOL-H
- CAS No.: 3637-10-3
- Formula:C9H19NO2
- Molecular Weight:173.25
IUPAC Name: 2,2,6,6-tetramethylpiperidine-1,4-diol
InChIKey: CSGAUKGQUCHWDP-UHFFFAOYSA-N
SMILES: OC1CC(C)(C)N(O)C(C)(C)C1
Biological Activity: TEMPOL-H is the reduced hydroxylamine form of the stable nitroxide radical Tempol (HY-100561), and serves as the active metabolite of OT-551 (HY-W556870). TEMPOL-H acts as a potent antioxidant and free radical scavenger. TEMPOL-H protects retinal pigment epithelial cells from acute light-induced damage, and protects mice from lethal whole-body radiation. TEMPOL-H inhibits lens opacification in mice, prevents glutathione loss in rat lenses under stress, blocks protein leakage in rhesus monkey lenses under stress, and maintains the 3H-choline accumulation capacity of the lens. TEMPOL-H can be used in studies related to light-induced retinal pigment epithelial degeneration and age-related cataract[1][2][3].
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TEMPOL-H | TEMPOL-H is the reduced hydroxylamine form of the stable nitroxide radical Tempol (HY-100561), and serves as the active metabolite of OT-551 (HY-W556870). TEMPOL-H acts as a potent antioxidant and free radical scavenger. TEMPOL-H protects retinal pigment epithelial cells from acute light-induced damage, and protects mice from lethal whole-body radiation. TEMPOL-H inhibits lens opacification in mice, prevents glutathione loss in rat lenses under stress, blocks protein leakage in rhesus monkey lenses under stress, and maintains the 3H-choline accumulation capacity of the lens. TEMPOL-H can be used in studies related to light-induced retinal pigment epithelial degeneration and age-related cataract. | |||||||||||||||||||||
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References
- [1]. Tanito M, et al. Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats. Experimental eye research. 2010 Jul;91(1):111-4. [Content Brief]
- [2]. Hahn SM, et al. Evaluation of the hydroxylamine Tempol-H as an in vivo radioprotector. Free radical biology & medicine. 2000 Mar 15;28(6):953-8.
- [3]. Zigler JS, et al. Tempol-H inhibits opacification of lenses in organ culture. Free radical biology & medicine. 2003 Nov 15;35(10):1194-202.
