36520-39-5
36520-39-5
Chemical Structure
Azetidine hydrochloride
Synonym(s): Trimethyleneimine hydrochloride
- CAS No.: 36520-39-5
- Formula:C3H8ClN
- Molecular Weight:93.56
IUPAC Name: azetidine hydrochloride
InChIKey: HGQULGDOROIPJN-UHFFFAOYSA-N
SMILES: C1CNC1.Cl
Biological Activity: Azetidine (Trimethyleneimine) hydrochloride is a four-membered saturated nitrogen-containing heterocyclic compound. Azetidine hydrochloride is often used as a building block or scaffold in chemical synthesis for the development of azetidine-based STAT3 inhibitors, GlyT1 inhibitors, and fluorophore modifiers[1][2][3][4].
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Azetidine hydrochloride | 97.0% | Azetidine (Trimethyleneimine) hydrochloride is a four-membered saturated nitrogen-containing heterocyclic compound. Azetidine hydrochloride is often used as a building block or scaffold in chemical synthesis for the development of azetidine-based STAT3 inhibitors, GlyT1 inhibitors, and fluorophore modifiers. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-W007768RHomopiperazine (Standard) -
Similarity Score 0.76
HY-W007359Thiomorpholine -
Similarity Score 0.74
HY-W0018454-Azepanone hydrochloride -
Similarity Score 0.73
HY-78871RN-Methylpiperazine (Standard) -
Similarity Score 0.73
HY-34767(R)-2-Methylpiperazine -
Similarity Score 0.70
HY-35279(S)-2-Methylazetidine hydrochloride -
Similarity Score 0.69
HY-40144Azetidin-3-ol hydrochloride -
Similarity Score 0.69
HY-W0016063-Fluoroazetidine hydrochloride -
Similarity Score 0.69
HY-W010525Piperidin-4-ylmethanamine -
Explore the MedChemAI to find more analogs
References
- [1]. Zhou J, et al. Azetidine-Containing Heterospirocycles Enhance the Performance of Fluorophores. Organic letters. 2020 Jun 05;22(11):4413-4417. [Content Brief]
- [2]. Hudson AR, et al. Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties. Bioorganic & medicinal chemistry letters. 2020 Jul 15;30(14):127214. [Content Brief]
- [3]. Yue P, et al. Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo. Cancer letters. 2022 May 28;534:215613.
- [4]. Brotherton-Pleiss C, et al. Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. Journal of medicinal chemistry. 2021 Jan 14;64(1):695-710. [Content Brief]
