Azetidine-Containing Heterospirocycles Enhance the Performance of Fluorophores

  • Org Lett. 2020 Jun 5;22(11):4413-4417. doi: 10.1021/acs.orglett.0c01414.
Junliang Zhou  1 ,  Xianfeng Lin  1 ,  Xin Ji  1 ,  Shuang Xu  1 ,  Chang Liu  1 ,  Xiaochun Dong  1 ,  Weili Zhao  1  2
Affiliations
  • 1. School of Pharmacy, Institutes of Integrative Medicine, Fudan University, Shanghai 201203, P.R. China.
  • 2. Key Laboratory for Special Functional Materials of the Ministry of Education, School of Materials Science and Engineering, Henan University, Kaifeng 475004, P.R. China.
PMID: 32462878 DOI: 10.1021/acs.orglett.0c01414
Abstract

Fluorescent dyes are extensively utilized in various fluorescence imaging techniques. However, many existing modification strategies could not balance the performance (such as brightness, photostability, water solubility, and permeability) of fluorophores. Herein we report a general strategy to enhance the performance of donor-acceptor-type fluorophores by introducing azetidine-containing heterospirocycles to the commonly used fluorophore scaffolds. Such a strategy turned out to be a general way to develop high-quality fluorophores.

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