365253-37-8
365253-37-8
Chemical Structure
Enzastaurin dihydrochloride
Synonym(s): LY317615 dihydrochloride
- CAS No.: 365253-37-8
- Formula:C32H31Cl2N5O2
- Molecular Weight:588.53
IUPAC Name: 3-(1-methyl-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)-1H-pyrrole-2,5-dione dihydrochloride
InChIKey: BOXDCOAZYDKDDE-UHFFFAOYSA-N
SMILES: O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O.[H]Cl.[H]Cl
Biological Activity: Enzastaurin (LY317615) dihydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε[1].
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Enzastaurin dihydrochloride | Enzastaurin (LY317615) dihydrochloride is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε. | |||||||||||||||||||||
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References
Keywords
