394668-43-0
394668-43-0
Chemical Structure
EBV lytic cycle inducer-1
- CAS. Nr.: 394668-43-0
- Formula:C14H12BrN3O
- Molecular Weight:318.17
InChIKey: GZJPBATWGXWPLE-LICLKQGHSA-N
SMILES: O=C(C1=CC(Br)=CC=C1)N/N=C(C)/C2=NC=CC=C2
Biological Activity: Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers[1][2].
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EBV lytic cycle inducer-1 | 96.24% | Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.68
HY-156776HAPSBC -
Similarity Score 0.65
HY-160191LSD1-IN-30 -
Similarity Score 0.64
HY-131649Compound C108 -
Similarity Score 0.63
HY-112914mTOR inhibitor-1 -
Similarity Score 0.63
HY-115847(E)-MS0017509 -
Similarity Score 0.62
HY-18634NSC319726 -
Similarity Score 0.62
HY-W007077(2-Amino-5-bromophenyl)(pyridin-2-yl)methanone -
Similarity Score 0.62
HY-W324882Salinazid -
Similarity Score 0.62
HY-162301P3FI-63 -
Explore the MedChemAI to find more analogs
References
- [1]. Chung King Choi, et al. Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies. PLoS One. 2015 Dec 30;10(12):e0145994.
- [2]. Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.
