4016-63-1
4016-63-1
Chemical Structure
8-Bromoguanosine
- CAS No.: 4016-63-1
- Formula:C10H12BrN5O5
- Molecular Weight:362.14
IUPAC Name: 2-amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
InChIKey: ASUCSHXLTWZYBA-UMMCILCDSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C2N=C(N)NC3=O)O1
Biological Activity: 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function[1][2][3].
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8-Bromoguanosine | 99.58% | 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function. | ||||||||||||||||||||
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8-Bromoguanosine-13C2,15N | 8-Bromoguanosine-13C2,15N is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function. | |||||||||||||||||||||
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8-Bromoguanosine-13C,15N2 | 8-Bromoguanosine-13C,15N2 is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function. | |||||||||||||||||||||
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References
- [1]. Goodman MG, Weigle WO. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides. Proc Natl Acad Sci U S A. 1984 Feb;81(3):862-6. [Content Brief]
- [2]. Koo GC, Jewell ME, Manyak CL, Sigal NH, Wicker LS. Activation of murine natural killer cells and macrophages by 8-bromoguanosine. J Immunol. 1988 May 1;140(9):3249-52. [Content Brief]
- [3]. Yajima R, et al. A conformationally restricted guanosine analog reveals the catalytic relevance of three structures of an RNA enzyme. Chem Biol. 2007 Jan;14(1):23-30. [Content Brief]
