415713-60-9
Chemical Structure
RI-1
- CAS No.: 415713-60-9
- Formula:C14H11Cl3N2O3
- Molecular Weight:361.61
IUPAC Name: 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
InChIKey: MWSUIZKGNWELRF-UHFFFAOYSA-N
SMILES: O=C(C(N1CCOCC1)=C2Cl)N(C3=CC=C(Cl)C(Cl)=C3)C2=O
Biological Activity: RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RI-1 | 99.83% | RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells. | ||||||||||||||||||||
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Keywords
