4733-39-5
Chemical Structure
Bathocuproine
- CAS No.: 4733-39-5
- Formula:C26H20N2
- Molecular Weight:360.46
IUPAC Name: 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline
InChIKey: STTGYIUESPWXOW-UHFFFAOYSA-N
SMILES: N=1C(=CC(C=2C=CC=CC2)=C3C=CC4=C(N=C(C=C4C=5C=CC=CC5)C)C13)C
Biological Activity: Bathocuproine is a phenanthroline chelator that binds specifically to Cu+. Bathocuproine preferentially binds Cu+ over Cu2+ to form a chromogenic complex, which is used to detect the oxidation state of copper in biomolecules. Bathocuproine undergoes concentration-dependent self-association to form dimers, and it can engage in aromatic stacking interactions with aromatic residues of Aβ (Kd ≈ 1 mM). Bathocuproine is applicable to research related to Alzheimer's disease[1][2].
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Bathocuproine | Bathocuproine is a phenanthroline chelator that binds specifically to Cu+. Bathocuproine preferentially binds Cu+ over Cu2+ to form a chromogenic complex, which is used to detect the oxidation state of copper in biomolecules. Bathocuproine undergoes concentration-dependent self-association to form dimers, and it can engage in aromatic stacking interactions with aromatic residues of Aβ (Kd ≈ 1 mM). Bathocuproine is applicable to research related to Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Chen D, et al. An improved Bathocuproine assay for accurate valence identification and quantification of copper bound by biomolecules. Anal Biochem. 2016;497:27-35. [Content Brief]
- [2]. Yao S, et al. Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR. J Pept Sci. 2004;10(4):210-217. [Content Brief]
Keywords
