501373-88-2
Chemical Structure
Milsaperidone
Synonym(s): (S)-Hydroxy Iloperidone; VHX-896
- CAS No.: 501373-88-2
- Formula:C24H29FN2O4
- Molecular Weight:428.50
IUPAC Name: (S)-1-(4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methoxyphenyl)ethan-1-ol
InChIKey: SBKZGLWZGZQVHA-INIZCTEOSA-N
SMILES: FC1=CC=C(C(C2CCN(CC2)CCCOC3=C(C=C(C=C3)[C@@H](O)C)OC)=NO4)C4=C1
Biological Activity: Milsaperidone ((S)-Hydroxy Iloperidone) is an active metabolite of the antipsychotic agent Iloperidone (HY-17410). Milsaperidone is a dopamine D2 and 5-HT2A receptor antagonist. Milsaperidone rapidly converts to Iloperidone when taken orally. Milsaperidone can be used in the research of mental illnesses such as depression[1][2].
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Milsaperidone | Milsaperidone ((S)-Hydroxy Iloperidone) is an active metabolite of the antipsychotic agent Iloperidone (HY-17410). Milsaperidone is a dopamine D2 and 5-HT2A receptor antagonist. Milsaperidone rapidly converts to Iloperidone when taken orally. Milsaperidone can be used in the research of mental illnesses such as depression. | |||||||||||||||||||||
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- [1]. Richmond L M. Med Check: FDA Accepts Bysanti Application, Cobenfy Fails as Adjunct, and More. 2025.
- [2]. IsHak WW, et al. Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pipeline phase 3 medications. BMC Psychiatry. 2025 Oct 7;25(1):939. [Content Brief]
Keywords
