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Cat. No.: HY-G0003A

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Milsaperidone

Name: Milsaperidone
Brand: MedChemExpress
SKU: HY-G0003A
Availability: PreOrder

(Synonyms: (S)-Hydroxy Iloperidone; VHX-896)

Milsaperidone ((S)-Hydroxy Iloperidone; VHX-896) is an orally active serotonin 5-HT2A and dopamine D2 receptor antagonist. Milsaperidone ((S)-Hydroxy Iloperidone) is the active metabolite of the antipsychotic agent Iloperidone (HY-17410). Milsaperidone can be used in studies related to mental disorders such as depression.

For research use only. We do not sell to patients.

CAS No.: 501373-88-2
Formula: C₂₄H₂₉FN₂O₄
Molecular Weight:428.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Milsaperidone Chemical Structure

CAS No.: 501373-88-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Dopamine Receptor Isoforms :

All 5-HT Receptor Isoforms :

In Vivo

Milsaperidone exerts direct dopamine D2 and serotonin 5-HT2A receptor antagonistic effects in vivo after oral administration. As the active metabolite of Iloperidone (HY-17410), it produces central neuroregulatory activity without requiring hepatic metabolic activation^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 501373-88-2
Molecular Weight 428.50
Formula C₂₄H₂₉FN₂O₄
SMILES

FC1=CC=C(C(C2CCN(CC2)CCCOC3=C(C=C(C=C3)[C@@H](O)C)OC)=NO4)C4=C1
Synonyms

(S)-Hydroxy Iloperidone; VHX-896
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. IsHak WW, et al. Depressive disorders: systematic review of approved psychiatric medications (2009-April 2025) and pipeline phase 3 medications. BMC psychiatry. 2025 Oct 07;25(1):939. [Content Brief]

[2]. Richmond L M. Med Check: FDA Accepts Bysanti Application, Cobenfy Fails as Adjunct, and More[J]. 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Milsaperidone

All Dopamine Receptor Isoforms

All 5-HT Receptor Isoforms