52450-38-1
52450-38-1
Chemical Structure
AFMK
- CAS No.: 52450-38-1
- Formula:C13H16N2O4
- Molecular Weight:264.28
IUPAC Name: N-(3-(2-formamido-5-methoxyphenyl)-3-oxopropyl)acetamide
InChIKey: JYWNYMJKURVPFH-UHFFFAOYSA-N
SMILES: CC(NCCC(C1=CC(OC)=CC=C1NC=O)=O)=O
Biological Activity: AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity[1][2]. AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AFMK | 99.97% | AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity. AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-W587743N1-Acetyl-5-methoxykynuramine hydrochloride -
Similarity Score 0.64
HY-28247N-Formylkynurenine -
Similarity Score 0.61
HY-115304UCM 793 -
Similarity Score 0.60
HY-138210N,O-Diacetyltyramine -
Similarity Score 0.58
HY-1807265-Hydroxykynurenine -
Similarity Score 0.58
HY-N19001(rac)-5-Hydroxykynurenine -
Similarity Score 0.58
HY-1331113-Hydroxy agomelatine -
Similarity Score 0.58
HY-17038ARAgomelatine hydrochloride (Standard) -
Similarity Score 0.58
HY-W142607Acebutolol impurity 3 -
Explore the MedChemAI to find more analogs
References
- [1]. Annia Galano, et al. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res. 2013 Apr;54(3):245-57. [Content Brief]
- [2]. Kailash Manda, et al. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res. 2007 Apr;42(4):386-93. [Content Brief]
- [3]. Anna Leja-Szpak, et al. Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1). Pharmacol Rep. 2018 Dec;70(6):1079-1088. [Content Brief]
