53-34-9
53-34-9
Chemical Structure
6α-Fluoroprednisolone
Synonym(s): Fluprednisolone
- CAS No.: 53-34-9
- Formula:C21H27FO5
- Molecular Weight:378.43
IUPAC Name: (6S,8S,9S,10R,11S,13S,14S,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: MYYIMZRZXIQBGI-HVIRSNARSA-N
SMILES: C[C@]1(C2)[C@](CC[C@@](O)1C(CO)=O)([H])[C@@](C[C@@H]3F)([H])[C@@]([C@H]2O)([H])[C@](C3=CC4=O)(C=C4)C
Biological Activity: 6α-Fluoroprednisolone (Fluprednisolone) serves as the internal standard for Methylprednisolone (HY-B0260), Prednisolone (HY-17463), and Prednisone (HY-B0214). 6α-Fluoroprednisolone is an anti-inflammatory agent with anti-inflammatory activity. 6α-Fluoroprednisolone exhibits thymolytic activity. 6α-Fluoroprednisolone functions as a natriuretic agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6α-Fluoroprednisolone | 6α-Fluoroprednisolone (Fluprednisolone) serves as the internal standard for Methylprednisolone (HY-B0260), Prednisolone (HY-17463), and Prednisone (HY-B0214). 6α-Fluoroprednisolone is an anti-inflammatory agent with anti-inflammatory activity. 6α-Fluoroprednisolone exhibits thymolytic activity. 6α-Fluoroprednisolone functions as a natriuretic agent. | |||||||||||||||||||||
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Paramethasone Acetate | 98.0% | Paramethasone Acetate is an orally active long-acting glucocorticoid. Paramethasone Acetate directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone Acetate suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone Acetate also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone Acetate inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone Acetate can be used in research related to osteoarthritis and endocrinology. | ||||||||||||||||||||
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Fluocortolone (Standard) | ≥98% | Fluocortolone (Standard) is the analytical standard of Fluocortolone. This product is intended for research and analytical applications. Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg). | ||||||||||||||||||||
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6β-Hydroxy prednisolone | 6β-Hydroxy prednisolone is a kind of biochemical reagent. | |||||||||||||||||||||
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Prednisolone | 99.93% | Prednisolone is a potent, orally active corticosteroid and a glucocorticoid. Prednisolone possesses about four times the anti-inflammatory activity of hydrocortisone while causing less salt and water retention. Prednisolone can be used for ocular, anti-inflammatory research. | ||||||||||||||||||||
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Paramethasone | Paramethasone is an orally active long-acting glucocorticoid. Paramethasone directly inhibits testicular aromatase, thereby reducing the synthesis of estradiol. Paramethasone suppresses the basal and midcycle luteinizing hormone surges in female animals and blocks estrogen synthesis. Paramethasone also decreases circulating levels of dihydrotestosterone, androstenedione and estradiol in male animals. Paramethasone inhibits cartilage degeneration and alleviates joint pathological damage in osteoarthritis models. Paramethasone can be used in research related to osteoarthritis and endocrinology. | |||||||||||||||||||||
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Methylprednisolone (Standard) | 98.90% | Methylprednisolone (Standard) is the analytical standard of Methylprednisolone. This product is intended for research and analytical applications. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. | ||||||||||||||||||||
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Methylprednisolone-d3-1 | Methylprednisolone-d3-1 (U 7532-d3-1) is the deuterium labeled Methylprednisolone (HY-B0260). Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. | |||||||||||||||||||||
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Methylprednisolone impurity 7 | Methylprednisolone impurity 7 is an impurity of Methylprednisolone. | |||||||||||||||||||||
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Methylprednisolone acetate impurity 3 | Methylprednisolone acetate impurity 3 is an impurity of Methylprednisolone acetate. | |||||||||||||||||||||
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Methylprednisolone impurity 8 | Methylprednisolone impurity 8 is an impurity of Methylprednisolone. | |||||||||||||||||||||
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References
- [1]. A. Bowers, et al. Steroids‑CXXI synthesis of halogenated steroid hormones: 6α‑fluoro cortical hormones a new class of powerful corticoids, Tetrahedron. 7 (1959) 153‑162.
- [2]. N. Bodor, et al. A theoretical study of prednisolone, 6α‑fluoroprednisolone, 9α‑fluoroprednisolone, 6α,9α‑difluoroprednisolone and related compounds, Journal of Molecular Structure: THEOCHEM. 279 (1993) 59‑69.
