54239-37-1
54239-37-1
Chemical Structure
Cimaterol
Synonym(s): CL 263780; (±)-2-Amino-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]benzonitrile
- CAS. Nr.: 54239-37-1
- Formula:C12H17N3O
- Molecular Weight:219.28
IUPAC Name: 2-amino-5-(1-hydroxy-2-(isopropylamino)ethyl)benzonitrile
InChIKey: BUXRLJCGHZZYNE-UHFFFAOYSA-N
SMILES: N#CC1=CC(C(O)CNC(C)C)=CC=C1N
Biological Activity: Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].
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Cimaterol | 99.24% | Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM). | ||||||||||||||||||||
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Cimaterol (Standard) | ≥98% | Cimaterol (Standard) is the analytical standard of Cimaterol. This product is intended for research and analytical applications. Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM). | ||||||||||||||||||||
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Cimaterol-d7 | 99.80% | Cimaterol-d7 is the deuterium labeled Cimaterol. Cimaterol is a potent agonist of β-adrenergic receptors (pEC50s=8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively). Cimaterol has been used in farmed animals to increase carcass mass and to alter muscle and fat deposition. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-131105Cimbuterol -
Similarity Score 0.73
HY-B0468RIsoprenaline hydrochloride (Standard) -
Similarity Score 0.73
HY-B1670A(-)-Isoproterenol hydrochloride -
Similarity Score 0.71
HY-131105SCimbuterol-d9 -
Similarity Score 0.70
HY-108302Nifenalol -
Similarity Score 0.70
HY-100699Clenproperol -
Similarity Score 0.69
HY-100952Nifenalol hydrochloride -
Similarity Score 0.68
HY-B1238Pronethalol -
Similarity Score 0.68
HY-B1238APronethalol hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. H C Walker, et al. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255(6 Pt 2):R952-60. [Content Brief]
- [2]. J M Harper, et al. The effects of beta agonists on muscle cells in culture. Domest Anim Endocrinol. 1990 Oct;7(4):477-84. [Content Brief]
