54845-95-3
54845-95-3
Chemical Structure
15(S)-HETE
- CAS 番号: 54845-95-3
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (S,5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid
InChIKey: JSFATNQSLKRBCI-VAEKSGALSA-N
SMILES: CCCCC[C@H](O)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
Biological Activity: 15(S)-HETE is an endogenous metabolite present in Urine that can be used for the research of Zellweger Syndrome[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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15(S)-HETE | 98.0% | 15(S)-HETE is an endogenous metabolite present in Urine that can be used for the research of Zellweger Syndrome. | ||||||||||||||||||||
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15(S)-HETE-d8 | 15(S)-HETE-d8 is the deuterium labeled 15(S)-HETE. | |||||||||||||||||||||
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12S-HHT | 98.45% | 12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. | ||||||||||||||||||||
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15(R)-HETE | 99.0% | 15(R)-HETE is an isomer of 15-HETE. 15-HETE is a lipid mediator derived from arachidonic acid and can be used for the study of asthma. | ||||||||||||||||||||
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(±)15-HETE | (±)15-HETE is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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5(S)-HETE | 98.9% | 5(S)-HETE is an endogenous metabolite present in Blood that can be used for the research of Rheumatoid Arthritis, Rhinitis and Asthma. | ||||||||||||||||||||
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5(R)-HETE | 5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes. | |||||||||||||||||||||
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5-HETE | 96.76% | 5-HETE ((±)-5-HETE), a fatty acid, is a oxidative derivative of Arachidonic acid. 5-HETE is a mixture of 5(S)-HETE and 5(R)-HETE. 5-HETE is a potent aggregating agent that induces the aggregation of neutrophils with an IC50 value of 200 nM. | ||||||||||||||||||||
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15(S)-HPETE | 97.32% | 15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies. | ||||||||||||||||||||
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15(S)-HETE methyl ester | 15(S)-HETE methyl ester (Methyl 15(S)-HETE) (compound 1) is a derivative of 15(S)-HETE (HY-113336), a endogenous metabolite presenting in Urine that can be used for the research of Zellweger Syndrome. 15(S)-HETE methyl ester is commonly used in formations of nutritional supplements. | |||||||||||||||||||||
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13(S)-Hydroxy-6(Z),9(Z),11(E)-octadecatrienoic acid | 13(S)-Hydroxy-6(Z),9(Z),11(E)-octadecatrienoic acid is an ester product. | |||||||||||||||||||||
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17(S)-HDoTE | 17(S)-HDoTE is a metabolite of Adrenic acid (HY-W013215). 17(S)-HDoTE is formed by the catalysis of Adrenic acid through 15-lipoxygenase (15-LO). | |||||||||||||||||||||
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References
- [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720. [Content Brief]
- [2]. Mayatepek E, et al. 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo. Pediatr Res. 1996 Jan;39(1):146-9. [Content Brief]
