550356-40-6
550356-40-6
Chemical Structure
seco-CBI-PBD dimer
- CAS No.: 550356-40-6
- Formula:C32H34ClN3O5
- Molecular Weight:576.08
InChIKey: ZKJWSGPAWIGGIX-RTWAWAEBSA-N
SMILES: ClC[C@H]1C2=C(C=C(C3=CC=CC=C32)O)N(C1)C(CCCCCOC4=C(C=C5C(N=C[C@@]6([H])N(CCC6)C5=O)=C4)OC)=O
Biological Activity: seco-CBI-PBD dimer is a CBI-PBD heterodimer and a minor groove DNA crosslinker. seco-CBI-PBD dimer exhibits cytotoxicity against human tumor cells at sub-pM to low nM levels, shows low sensitivity to P-glycoprotein-mediated drug resistance, and can serve as an ADC payload. seco-CBI-PBD dimer can be used in studies of uterine cancer, breast cancer, non-small cell lung cancer, etc.[1]
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seco-CBI-PBD dimer | seco-CBI-PBD dimer is a CBI-PBD heterodimer and a minor groove DNA crosslinker. seco-CBI-PBD dimer exhibits cytotoxicity against human tumor cells at sub-pM to low nM levels, shows low sensitivity to P-glycoprotein-mediated drug resistance, and can serve as an ADC payload. seco-CBI-PBD dimer can be used in studies of uterine cancer, breast cancer, non-small cell lung cancer, etc. | |||||||||||||||||||||
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