5633-14-7
Chemical Structure
Benzetimide hydrochloride
Synonym(s): R4929; Dioxatrine
- CAS No.: 5633-14-7
- Formula:C23H27ClN2O2
- Molecular Weight:398.93
IUPAC Name: 1'-benzyl-3-phenyl-[3,4'-bipiperidine]-2,6-dione hydrochloride
InChIKey: XSOOSXRNMDUWEM-UHFFFAOYSA-N
SMILES: O=C(C(C1CCN(CC2=CC=CC=C2)CC1)(C3=CC=CC=C3)CC4)NC4=O.[H]Cl
Biological Activity: Benzetimide hydrochloride (R4929) is a blood-brain barrier-permeable muscarinic acetylcholine receptor antagonist. Benzetimide hydrochloride blocks cholinergic receptor sites. Benzetimide hydrochloride induces mydriasis, prevents acetylcholine-induced muscle contraction, inhibits pilocarpine (HY-B0726A)-induced parasympathomimetic effects, and exhibits antisecretory activity. Benzetimide hydrochloride can be used in research related to Parkinson's disease[1][2].
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Benzetimide hydrochloride | 99.44% | Benzetimide hydrochloride (R4929) is a blood-brain barrier-permeable muscarinic acetylcholine receptor antagonist. Benzetimide hydrochloride blocks cholinergic receptor sites. Benzetimide hydrochloride induces mydriasis, prevents acetylcholine-induced muscle contraction, inhibits pilocarpine (HY-B0726A)-induced parasympathomimetic effects, and exhibits antisecretory activity. Benzetimide hydrochloride can be used in research related to Parkinson's disease. | ||||||||||||||||||||
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Benzetimide hydrochloride (Standard) | ≥98% | Benzetimide hydrochloride (Standard) (R4929 (Standard); Dioxatrine (Standard)) is the analytical standard of Benzetimide hydrochloride (HY-B1547A). This product is intended for research and analytical applications. Benzetimide hydrochloride (R4929) is a blood-brain barrier-permeable muscarinic acetylcholine receptor antagonist. Benzetimide hydrochloride blocks cholinergic receptor sites. Benzetimide hydrochloride induces mydriasis, prevents acetylcholine-induced muscle contraction, inhibits pilocarpine (HY-B0726A)-induced parasympathomimetic effects, and exhibits antisecretory activity. Benzetimide hydrochloride can be used in research related to Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. van Wijngaarden I. Differential anticholinergic activity, metabolism and excretion of the optical isomers of 14C-benzetimide hydrochloride. Life Sci. 1969 May 1;8(9):517-23. [Content Brief]
- [2]. Janssen PA, et al. The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in rats. Psychopharmacologia. 1967 Aug 4;11(3):231-54. [Content Brief]
