5845-26-1
5845-26-1
Chemical Structure
Thiazesim
- CAS No.: 5845-26-1
- Formula:C19H22N2OS
- Molecular Weight:326.46
IUPAC Name: 5-(2-(dimethylamino)ethyl)-2-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
InChIKey: QJJXOEFWXSQISU-UHFFFAOYSA-N
SMILES: O=C1N(C=2C=CC=CC2SC(C=3C=CC=CC3)C1)CCN(C)C
Biological Activity: Thiazesim is a CNS-penetrant GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim depresses amygdala output, disrupts conditioned avoidance response in rats. Thiazesim can be used for the research of depression and epilepsy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Thiazesim | Thiazesim is a CNS-penetrant GABAA receptor inhibitor, exerting anticonvulsant and antidepressant effects. Thiazesim depresses amygdala output, disrupts conditioned avoidance response in rats. Thiazesim can be used for the research of depression and epilepsy. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Barratt ES. The effects of thiazesim, LSD-25, and bilateral lesions of the amygdalae on the release of a suppressed response. Recent Adv Biol Psychiatry. 1966;9:229-40. [Content Brief]
- [2]. Bell R, et al. The effects of two "anti-aggressive" compounds, an indenopyridine and a benzothiazepin, on shock-induced defensive fighting in rats. Prog Neuropsychopharmacol. 1979;3(4):399-402. [Content Brief]
- [3]. Dreyfuss J, et al. Metabolism of Thiazesim, 5-(2-Dimethylaminoethyl)-2,3-Dihydro-2-Phenyl-1,5-Benzothiazepin-4(5H)-One, in the Rat In Vivo and In Vitro. Journal of Pharmaceutical Sciences 1968, 57 (9), 1505-1511.
- [4]. Marques, et al. Conditioned avoidance deficits induced in rats by an amygdala depressant, Thiazesim HCl.
- [5]. Geyer HM 3rd, et al. Effects of a tranquilizer and two antidepressants on learned and unlearned behaviors. J Pharm Sci. 1970 Jul;59(7):964-8. [Content Brief]
Keywords
