591207-53-3
Chemical Structure
(E/Z)-Dacinostat
Synonym(s): (E/Z)-NVP-LAQ824; (E/Z)-LAQ824
- CAS No.: 591207-53-3
- Formula:C22H25N3O3
- Molecular Weight:379.45
IUPAC Name: (E)-3-(4-(((2-(1H-indol-2-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide
InChIKey: FGJCGXHQLHHNFO-MDZDMXLPSA-N
SMILES: O=C(/C=C/C1=CC=C(C=C1)CN(CCC2=CC3=C(C=CC=C3)N2)CCO)NO
Biological Activity: (E/Z)-Dacinostat ((E/Z)-NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z)-Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways.
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(E/Z)-Dacinostat | (E/Z)-Dacinostat ((E/Z)-NVP-LAQ824) is a histone deacetylase inhibitor that has the ability to induce apoptosis and enhance the activity of fludarabine in killing leukemia cells. (E/Z)-Dacinostat can trigger the production of reactive oxygen species (ROS) and DNA damage, enhance the killing effect of fludarabine on leukemia cells, and induce apoptosis. Its mechanism is related to the regulation of DNA repair processes and intracellular signaling pathways. | |||||||||||||||||||||
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