59937-28-9
Chemical Structure
Malotilate
Synonym(s): NKK 105
- CAS No.: 59937-28-9
- Formula:C12H16O4S2
- Molecular Weight:288.38
IUPAC Name: diisopropyl 2-(1,3-dithiol-2-ylidene)malonate
InChIKey: YPIQVCUJEKAZCP-UHFFFAOYSA-N
SMILES: O=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS\1
Biological Activity: Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes[1][2].
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Malotilate | 99.47% | Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes. | ||||||||||||||||||||
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Malotilate (Standard) | ≥98% | Malotilate (Standard) is the analytical standard of Malotilate. This product is intended for research and analytical applications. Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes. | ||||||||||||||||||||
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- [1]. Matsuda Y, et al. Effects of malotilate on alcoholic liver injury in rats. Alcohol Clin Exp Res. 1988;12(5):665-670. [Content Brief]
- [2]. Vermeer MA, Wilson JH, Zijlstra FJ, Vincent JE. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Agents Actions. 1989;26(1-2):252-253. [Content Brief]
Keywords
