60200-06-8
Chemical Structure
Clorsulon
Synonym(s): L631529; MK401
- CAS No.: 60200-06-8
- Formula:C8H8Cl3N3O4S2
- Molecular Weight:380.66
IUPAC Name: 4-amino-6-(1,2,2-trichlorovinyl)benzene-1,3-disulfonamide
InChIKey: QOVTVIYTBRHADL-UHFFFAOYSA-N
SMILES: O=S(C1=C(/C(Cl)=C(Cl)\Cl)C=C(N)C(S(=O)(N)=O)=C1)(N)=O
Biological Activity: Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep[1][2][3][4][5][6].
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Clorsulon | 99.99% | Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep. | ||||||||||||||||||||
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Clorsulon (Standard) | ≥98% | Clorsulon (Standard) is the analytical standard of Clorsulon (HY-B0488). This product is intended for research and analytical applications. Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep. | ||||||||||||||||||||
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- [1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7. [Content Brief]
- [2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41. [Content Brief]
- [3]. Meaney M, et al. A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica. Parasitol Res. 2005 Jan;95(2):117-28. [Content Brief]
- [4]. Blanco-Paniagua E, et al. Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin. Antimicrob Agents Chemother. 2023 May 17;67(5):e0009523. [Content Brief]
- [5]. Rehbein S, et al. Plasma pharmacokinetics of clorsulon following administration of a single subcutaneous or intravenous injection to cattle. J Vet Pharmacol Ther. 2024 Mar;47(2):87-94. [Content Brief]
- [6]. Lankas GR, et al. Induction of reversible urothelial cell hyperplasia in rats by clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity. Food Chem Toxicol. 1992 Apr;30(4):297-306. [Content Brief]
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