4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

  • J Med Chem. 1977 Sep;20(9):1225-7. doi: 10.1021/jm00219a025.
H Mrozik ,  R J Bochis ,  P Eskola ,  A Matzuk ,  S Waksmunski ,  L E Olen ,  G Schwartzkopf Jr ,  A Grodski ,  B O Linn ,  A Lusi ,  M T Wu ,  C H Shunk ,  L H Peterson ,  J D Milkowski ,  D R Hoff ,  P Kulsa ,  D A Ostlind ,  W C Campbell ,  R F Riek ,  R E Harmon
PMID: 926125 DOI: 10.1021/jm00219a025
Abstract

The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after Infection) and calves (8 weeks after Infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

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