1. Anti-infection
  2. Parasite
  3. Clorsulon

Clorsulon (Synonyms: L631529; MK401)

Cat. No.: HY-B0488 Purity: >98.0%
Handling Instructions

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

For research use only. We do not sell to patients.

Clorsulon Chemical Structure

Clorsulon Chemical Structure

CAS No. : 60200-06-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
500 mg USD 192 In-stock
Estimated Time of Arrival: December 31
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Description

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep. Target: Antiparasitic Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2].

Molecular Weight

380.66

Formula

C₈H₈Cl₃N₃O₄S₂

CAS No.

60200-06-8

SMILES

O=S(C1=C(/C(Cl)=C(Cl)\Cl)C=C(N)C(S(=O)(N)=O)=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (262.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6270 mL 13.1351 mL 26.2702 mL
5 mM 0.5254 mL 2.6270 mL 5.2540 mL
10 mM 0.2627 mL 1.3135 mL 2.6270 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ClorsulonL631529MK401L 631529L-631529MK 401MK-401ParasiteInhibitorinhibitorinhibit

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Clorsulon
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