60388-53-6
60388-53-6
Chemical Structure
(±)-Methotrexate
Synonym(s): (±)-Amethopterin; (±)-CL14377; (±)-WR19039
- CAS No.: 60388-53-6
- Formula:C20H22N8O5
- Molecular Weight:454.44
IUPAC Name: (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)glutamic acid
InChIKey: FBOZXECLQNJBKD-UHFFFAOYSA-N
SMILES: O=C(C(CCC(O)=O)NC(C1=CC=C(C=C1)N(C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)O
Biological Activity: (±)-Methotrexate ((±)-Amethopterin) is a racemate of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis[1].
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(±)-Methotrexate | (±)-Methotrexate ((±)-Amethopterin) is a racemate of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis. | |||||||||||||||||||||
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Amethopterin-d3 | Amethopterin-d3 is deuterium labeled Amethopterin. | |||||||||||||||||||||
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(±)-Methotrexate-13C,d3 disodium | (±)-Methotrexate-13C,d3 disodium ((±)-Amethopterin-13C,d3 disodium) is the 13C-labeled (±)-Methotrexate disodium. (±)-Methotrexate ((±)-Amethopterin) is a racemate of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis. | |||||||||||||||||||||
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References
