625403-59-0
625403-59-0
Chemical Structure
SBI-183
- CAS No.: 625403-59-0
- Formula:C18H20N2O2
- Molecular Weight:296.36
InChIKey: ZZJGTLJERDOEQV-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OC)=CC=C1)NC2=CC=C(N3CCCC3)C=C2
Biological Activity: SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo [1].
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SBI-183 | 99.8% | SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo . | ||||||||||||||||||||
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