643-56-1
Chemical Structure
Dracorhodin
- CAS No.: 643-56-1
- Formula:C17H14O3
- Molecular Weight:266.29
IUPAC Name: 5-methoxy-6-methyl-2-phenyl-7H-chromen-7-one
InChIKey: UCZJPQIEFFTIEV-UHFFFAOYSA-N
SMILES: O=C(C(C)=C1OC)C=C2C1=CC=C(C3=CC=CC=C3)O2
Biological Activity: Dracorhodin is a natural product that can be obtained from the natural active molecule Dragon's blood. Dracorhodin inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin regulates the TLR4. Dracorhodin promotes wound healing, improves diabetes. Dracorhodin has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dracorhodin | 96.76% | Dracorhodin is a natural product that can be obtained from the natural active molecule Dragon's blood. Dracorhodin inhibits PI3K/Akt and NF-κB activation, upregulates p53 expression, activates caspase, produces ROS, and promotes Apoptosis. Dracorhodin regulates the TLR4. Dracorhodin promotes wound healing, improves diabetes. Dracorhodin has anti-tumor activity against prostate cancer, breast cancer, cervical cancer and other cancers. | ||||||||||||||||||||
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Similarity Score 0.81
HY-N18324Nordracorhodin -
Similarity Score 0.68
HY-1319972'MeO6MF -
Similarity Score 0.66
HY-W097625R6-Methoxyflavone (Standard) -
Similarity Score 0.66
HY-N88222'-Methoxyflavone -
Similarity Score 0.66
HY-N8487R7-Methoxyflavone (Standard) -
Similarity Score 0.66
HY-107790R5-Methoxyflavone (Standard) -
Similarity Score 0.65
HY-1683216-Hydroxy-2′-methoxyflavone -
Similarity Score 0.64
HY-14592RTectochrysin (Standard) -
Similarity Score 0.64
HY-N15307Trigraecum -
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References
- [1]. Rasul A, et al. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct;17(10):1104-19. [Content Brief]
- [2]. Xia M, et al. Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci. 2004 Jun;95(2):273-83. [Content Brief]
- [3]. Jiang X, et al. Dracorhodin perchlorate regulates fibroblast proliferation to promote rat's wound healing. J Pharmacol Sci. 2018 Feb;136(2):66-72. [Content Brief]
- [4]. He Y, et al. Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3. J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):215. [Content Brief]
- [5]. Yu JH, et al. Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways. Int J Med Sci. 2013 Jul 7;10(9):1149-56. [Content Brief]
- [6]. Xiong Z, et al. Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats. Evid Based Complement Alternat Med. 2022 Apr 14;2022:9050686. [Content Brief]
- [7]. Liu L, et al. Dracorhodin perchlorate protects pancreatic β-cells against glucotoxicity- or lipotoxicity-induced dysfunction and apoptosis in vitro and in vivo. FEBS J. 2019 Sep;286(18):3718-3736. [Content Brief]
- [8]. Chen X, et al. Dracorhodin perchlorate induces the apoptosis of glioma cells. Oncol Rep. 2016 Apr;35(4):2364-72. [Content Brief]
