65-15-6
65-15-6
Chemical Structure
Azapetine hydrochloride
- CAS. Nr.: 65-15-6
- Formula:C17H18ClN
- Molecular Weight:271.78
IUPAC Name: 6-allyl-6,7-dihydro-5H-dibenzo[c,e]azepine hydrochloride
InChIKey: PAGNTBKVOFUKLT-UHFFFAOYSA-N
SMILES: C=CCN1CC2=C(C3=C(C1)C=CC=C3)C=CC=C2.Cl
Biological Activity: Azapetine hydrochloride is a selective α1-adrenergic receptor inhibitor with an IC50 of 205 nM. Azapetine hydrochloride inhibits Epinephrine (HY-B0447)-induced platelet aggregation, slightly enhances the contractile response of isolated rat vas deferens, and blocks α1 and α2 adrenergic receptor-mediated vasoconstriction[1][2].
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Azapetine hydrochloride | Azapetine hydrochloride is a selective α1-adrenergic receptor inhibitor with an IC50 of 205 nM. Azapetine hydrochloride inhibits Epinephrine (HY-B0447)-induced platelet aggregation, slightly enhances the contractile response of isolated rat vas deferens, and blocks α1 and α2 adrenergic receptor-mediated vasoconstriction. | |||||||||||||||||||||
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References
- [1]. Ishida Y, et al. Alpha-adrenolytic properties of apogalanthamine and azapetine analogs. Journal of pharmacobio-dynamics. 1985 Nov;8(11):917-23. [Content Brief]
- [2]. Timmermans PB, et al. Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. Journal of medicinal chemistry. 1984 Apr;27(4):495-503. [Content Brief]
Keywords
