Azapetine hydrochloride
Azapetine hydrochloride is a selective α1-adrenergic receptor inhibitor with an IC50 of 205 nM. Azapetine hydrochloride inhibits Epinephrine (HY-B0447)-induced platelet aggregation, slightly enhances the contractile response of isolated rat vas deferens, and blocks α1 and α2 adrenergic receptor-mediated vasoconstriction.
For research use only. We do not sell to patients.
- CAS No.: 65-15-6
- Formula: C17H18ClN
- Molecular Weight:271.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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α1-adrenergic receptor 205 nM (IC50) |
α2-adrenergic receptor 1.3 μM (IC50) |
Azapetine hydrochloride weakly inhibits Epinephrine (HY-B0447)-induced platelet aggregation, with an IC50 value of 28.9 μM[1].
Azapetine hydrochloride inhibits the specific [3H]Prazosin binding to α1-adrenergic receptors in crude rat brain membranes, with an IC50 of 205 nM[2].
Azapetine hydrochloride inhibits the binding of specific [3H]clonidine to α2-adrenergic receptors in crude rat brain membranes, with an IC50 of 1.3 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65-15-6
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Molecular Weight 271.78
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Formula C17H18ClN
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SMILES
C=CCN1CC2=C(C3=C(C1)C=CC=C3)C=CC=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ishida Y, et al. Alpha-adrenolytic properties of apogalanthamine and azapetine analogs. Journal of pharmacobio-dynamics. 1985 Nov;8(11):917-23. [Content Brief]
[2]. Timmermans PB, et al. Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. Journal of medicinal chemistry. 1984 Apr;27(4):495-503. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Azapetine hydrochloride Related Classifications
HY-W745352 Related Classifications
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