Azapetine hydrochloride
Azapetine hydrochloride is a selective α1-adrenergic receptor inhibitor with an IC50 of 205 nM. Azapetine hydrochloride inhibits Epinephrine (HY-B0447)-induced platelet aggregation, slightly enhances the contractile response of isolated rat vas deferens, and blocks α1 and α2 adrenergic receptor-mediated vasoconstriction.
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- CAS. Nr.: 65-15-6
- Formel: C17H18ClN
- Molecular Weight:271.78
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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α1-adrenergic receptor 205 nM (IC50) |
α2-adrenergic receptor 1.3 μM (IC50) |
Azapetine hydrochloride weakly inhibits Epinephrine (HY-B0447)-induced platelet aggregation, with an IC50 value of 28.9 μM[1].
Azapetine hydrochloride inhibits the specific [3H]Prazosin binding to α1-adrenergic receptors in crude rat brain membranes, with an IC50 of 205 nM[2].
Azapetine hydrochloride inhibits the binding of specific [3H]clonidine to α2-adrenergic receptors in crude rat brain membranes, with an IC50 of 1.3 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 65-15-6
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Molecular Weight 271.78
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Formel C17H18ClN
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SMILES
C=CCN1CC2=C(C3=C(C1)C=CC=C3)C=CC=C2.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Ishida Y, et al. Alpha-adrenolytic properties of apogalanthamine and azapetine analogs. Journal of pharmacobio-dynamics. 1985 Nov;8(11):917-23. [Content Brief]
[2]. Timmermans PB, et al. Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. Journal of medicinal chemistry. 1984 Apr;27(4):495-503. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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