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Art. -Nr.: HY-181635

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Azapetine

Azapetine is an α-adrenergic receptor antagonist, with a IC₅₀ of 0.205 μM against rat α₁-adrenergic receptors and a IC₅₀ of 1.3 μM against rat α₂-adrenergic receptors. Azapetine blocks α1/α2-adrenergic receptor-mediated contraction of blood vessels and vascular smooth muscles. Azapetine can be used for the research of peripheral vascular diseases.

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CAS. Nr.: 146-36-1
Formel: C₁₇H₁₇N
Molecular Weight:235.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Azapetine Chemical Structure

CAS. Nr.: 146-36-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

rat α1-adrenergic receptor

0.205 μM (IC₅₀)

rat α2-adrenergic receptor

1.3 μM (IC₅₀)

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Azapetine (45-60 min) exhibits higher binding affinity for α₁-adrenergic receptors than for α₂-adrenergic receptors in isolated rat brain cell membranes, with an IC₅₀ of 0.205 μM for α₁-adrenergic receptors and 1.3 μM for α₂-adrenergic receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Azapetine (intravenous administration) exhibits in vivo functional blockade selectivity for α₁-adrenergic receptors over α₂-adrenergic receptors in normotensive decerebrate-spinal Wistar rats, with a logarithmic selectivity ratio of 1.21^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 146-36-1
Molecular Weight 235.32
Formel C₁₇H₁₇N
SMILES

C=CCN1CC2=C(C3=C(C1)C=CC=C3)C=CC=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Timmermans PB, et al. Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists. J Med Chem. 1984;27(4):495-503. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Azapetine

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Azapetine Related Classifications

HY-181635 Related Classifications