2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Azapetine

Azapetine is an α-adrenergic receptor antagonist, with a IC50 of 0.205 μM against rat α1-adrenergic receptors and a IC50 of 1.3 μM against rat α2-adrenergic receptors. Azapetine blocks α1/α2-adrenergic receptor-mediated contraction of blood vessels and vascular smooth muscles. Azapetine can be used for the research of peripheral vascular diseases.

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Azapetine

Azapetine Chemical Structure

CAS No. : 146-36-1

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Azapetine Related Antibodies

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Description

Azapetine is an α-adrenergic receptor antagonist, with a IC50 of 0.205 μM against rat α1-adrenergic receptors and a IC50 of 1.3 μM against rat α2-adrenergic receptors. Azapetine blocks α1/α2-adrenergic receptor-mediated contraction of blood vessels and vascular smooth muscles. Azapetine can be used for the research of peripheral vascular diseases[1].

IC50 & Target[1]

rat α1-adrenergic receptor

0.205 μM (IC50)

rat α2-adrenergic receptor

1.3 μM (IC50)

In Vitro

Azapetine (45-60 min) exhibits higher binding affinity for α1-adrenergic receptors than for α2-adrenergic receptors in isolated rat brain cell membranes, with an IC50 of 0.205 μM for α1-adrenergic receptors and 1.3 μM for α2-adrenergic receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azapetine Related Antibodies
In Vivo

Azapetine (intravenous administration) exhibits in vivo functional blockade selectivity for α1-adrenergic receptors over α2-adrenergic receptors in normotensive decerebrate-spinal Wistar rats, with a logarithmic selectivity ratio of 1.21[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

235.32

Formula

C17H17N
CAS No.
SMILES

C=CCN1CC2=C(C3=C(C1)C=CC=C3)C=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Azapetine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azapetine146-36-1Adrenergic ReceptorBeta Receptorα-adrenergic receptor antagonistperipheral vascular diseasesInhibitorinhibitorinhibit

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