65813-55-0
65813-55-0
Chemical Structure
1-Oxo Ibuprofen
Synonym(s): Ibuprofen EP impurity J
- CAS No.: 65813-55-0
- Formula:C13H16O3
- Molecular Weight:220.26
IUPAC Name: 2-(4-isobutyrylphenyl)propanoic acid
InChIKey: RCINGEKPKJQCMO-UHFFFAOYSA-N
SMILES: O=C(O)C(C)C1=CC=C(C(C(C)C)=O)C=C1
Biological Activity: 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].
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1-Oxo Ibuprofen | 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively. | |||||||||||||||||||||
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1-Oxo Ibuprofen (Standard) | ≥98% | 1-Oxo Ibuprofen (Standard) is the analytical standard of 1-Oxo Ibuprofen. This product is intended for research and analytical applications. 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively. | ||||||||||||||||||||
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References
- [1]. YongFang Rao, et al. Degradation of ibuprofen by a synergistic UV/Fe(III)/Oxone process. Chemical Engineering Journal. Volume 283, 1 January 2016, Pages 65-75.
- [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. [Content Brief]
