66635-93-6
66635-93-6
Chemical Structure
(R)-Ketorolac
Synonym(s): (+)-Ketorolac
- CAS No.: 66635-93-6
- Formula:C15H13NO3
- Molecular Weight:255.27
IUPAC Name: (R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
InChIKey: OZWKMVRBQXNZKK-LLVKDONJSA-N
SMILES: O=C(C1=CC=CC=C1)C2=CC=C3N2CC[C@H]3C(O)=O
Biological Activity: (R)-Ketorolac is an orally active Cdc42 and Rac1 inhibitor. (R)-Ketorolac inhibits GTPase. (R)-Ketorolac alters ovarian cancer cell behaviors critical for invasion and metastasis. (R)-Ketorolac ameliorates cancer-associated cachexia[1][2][3].
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(R)-Ketorolac | 99.35% | (R)-Ketorolac is an orally active Cdc42 and Rac1 inhibitor. (R)-Ketorolac inhibits GTPase. (R)-Ketorolac alters ovarian cancer cell behaviors critical for invasion and metastasis. (R)-Ketorolac ameliorates cancer-associated cachexia. | ||||||||||||||||||||
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References
- [1]. Handley DA, et al. Preclinical enantioselective pharmacology of (R)- and (S)- ketorolac. J Clin Pharmacol. 1998 Feb;38(2S):25S-35S. [Content Brief]
- [2]. Guo Y, Kenney SR, Muller CY, et al. R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther. 2015;14(10):2215-2227. [Content Brief]
- [3]. Chrysostomou SE, et al. R-ketorolac ameliorates cancer-associated cachexia and prolongs survival of tumour-bearing mice. J Cachexia Sarcopenia Muscle. 2024 Apr;15(2):562-574. [Content Brief]
