67450-45-7
Chemical Structure
Eclanamine maleate
- CAS No.: 67450-45-7
- Formula:C20H26Cl2N2O5
- Molecular Weight:445.34
IUPAC Name: N-(3,4-dichlorophenyl)-N-((1R,2R)-2-(dimethylamino)cyclopentyl)propionamide maleate
InChIKey: ZEUQHGFLDLNEOB-CHHFXETESA-N
SMILES: CCC(N(C1=CC=C(Cl)C(Cl)=C1)[C@H]2[C@H](N(C)C)CCC2)=O.O=C(O)/C=C\C(O)=O
Biological Activity: Eclanamine maleate is an orally effective non-tricyclic antidepressant and an adrenergic receptor modulator. Eclanamine maleate blocks biogenic amine uptake and enhances α2-receptor sensitivity, and long-term administration induces downregulation and desensitization of cortical β-receptors. Eclanamine maleate is used in the study of depression[1][2][3][4].
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Eclanamine maleate | Eclanamine maleate is an orally effective non-tricyclic antidepressant and an adrenergic receptor modulator. Eclanamine maleate blocks biogenic amine uptake and enhances α2-receptor sensitivity, and long-term administration induces downregulation and desensitization of cortical β-receptors. Eclanamine maleate is used in the study of depression. | |||||||||||||||||||||
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References
- [1]. Lakings DB, et al. High-performance liquid chromatographic method for the determination of eclanamine and its N-desmethyl and N,N-didesmethyl metabolites in urine. J Chromatogr. 1988 Jun 24;428(1):131-9.
- [2]. Aaron CS, et al. Risk and benefit evaluation in development of pharmaceutical products. Environ Health Perspect.
- [3]. Sethy VH, et al. Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. 1988;12(5):673-82.
- [4]. Szmuszkovicz J, et al. A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds. J Med Chem. 1981 Oct;24(10):1230-6. [Content Brief]
