689-13-4
Chemical Structure
Hadacidin
- CAS No.: 689-13-4
- Formula:C3H5NO4
- Molecular Weight:119.08
IUPAC Name: N-formyl-N-hydroxyglycine
InChIKey: URJHVPKUWOUENU-UHFFFAOYSA-N
SMILES: O=C(O)CN(O)C=O
Biological Activity: Hadacidin is a competitive inhibitor of adenylate synthase, possessing antitumor, plant growth inhibitory, and other activities. Hadacidin competitively inhibits aspartate binding, blocking the formation of adenylosuccinate, the reamination of IMP, and de novo adenine nucleotide synthesis. Hadacidin inhibits mitosis and plant stem/root growth. Hadacidin induces mesenchymal/epithelial cell death at high concentrations. Hadacidin can be used in plant growth regulation and cancer-related research[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hadacidin | 96.27% | Hadacidin is a competitive inhibitor of adenylate synthase, possessing antitumor, plant growth inhibitory, and other activities. Hadacidin competitively inhibits aspartate binding, blocking the formation of adenylosuccinate, the reamination of IMP, and de novo adenine nucleotide synthesis. Hadacidin inhibits mitosis and plant stem/root growth. Hadacidin induces mesenchymal/epithelial cell death at high concentrations. Hadacidin can be used in plant growth regulation and cancer-related research. | ||||||||||||||||||||
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Similarity Score 0.82
HY-126055AHadacidin sodium -
Similarity Score 0.76
HY-128735N-Formylglycine -
Similarity Score 0.76
HY-244863-Oxopropanoic acid -
Similarity Score 0.75
HY-104071Succinaldehydic acid -
Similarity Score 0.74
HY-W188178N-Mitrososarcosine -
Similarity Score 0.73
HY-W007872N-Methyliminodiacetic acid -
Similarity Score 0.73
HY-W8571475-Oxopentanoic acid -
Similarity Score 0.72
HY-W001158N,N-Dimethylglycine hydrochloride -
Similarity Score 0.72
HY-Y0511N,N-Dimethylglycine -
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References
- [1]. Dye FJ, et al. Inhibition of mouse molar morphogenesis in vitro by hadacidin. Pathobiology. 1978 Oct 3;46(3):152-69. [Content Brief]
- [2]. Gray RA, et al. Hadacidin, a new plant-growth inhibitor produced by fermentation. Plant physiology. 1964 Mar;39(2):204. [Content Brief]
- [3]. Meyer RA, et al. AMP deamination and IMP reamination in working skeletal muscle. The American journal of physiology. 1980 Jul;239(1):C32-8. [Content Brief]
- [4]. Meyer RA, et al. Ammonia and IMP in different skeletal muscle fibers after exercise in rats. Journal of Applied Physiology. 1980 Dec 1;49(6):1037-41. [Content Brief]
- [5]. Rossomando EF, et al. Effect of hadacidin on growth and adenylosuccinate synthetase activity of Dictyostelium discoideum. Antimicrobial Agents and Chemotherapy. 1978 Sep;14(3):476-82. [Content Brief]
- [6]. Ellison RR. Preliminary clinical trials of hadacidin, et al. Clinical Pharmacology & Therapeutics. 1963 May;4(3):326-9.
