724709-68-6
Chemical Structure
Psora-4
Synonym(s): 5-(4-Phenylbutoxy)psoralen
- CAS. Nr.: 724709-68-6
- Formula:C21H18O4
- Molecular Weight:334.37
IUPAC Name: 4-(4-phenylbutoxy)-7H-furo[3,2-g]chromen-7-one
InChIKey: JJAWGNIQEOFURP-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(OCCCCC3=CC=CC=C3)C4=C(OC=C4)C=C2O1
Biological Activity: Psora-4 (5-(4-Phenylbutoxy) psoralen) is a selective Kv1.3 blocker (Kd = 3 nM). Psora-4 increases mitochondrial ROS production, activates stress response genes including daf-16 targets and heat shock proteins, reduces triglyceride accumulation, extends lifespan and healthspan in C. elegans, and increases resistance to Paraquat-induced oxidative stress. Psora-4 can be used for research on psoriasis and obesity[1][2][3][4][5].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Psora-4 | 99.7% | Psora-4 (5-(4-Phenylbutoxy) psoralen) is a selective Kv1.3 blocker (Kd = 3 nM). Psora-4 increases mitochondrial ROS production, activates stress response genes including daf-16 targets and heat shock proteins, reduces triglyceride accumulation, extends lifespan and healthspan in C. elegans, and increases resistance to Paraquat-induced oxidative stress. Psora-4 can be used for research on psoriasis and obesity. | ||||||||||||||||||||
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References
- [1]. Luo G, et al. An allosteric pocket in KV1. 3 defines a distinct chemical space for immunomodulator design[J]. bioRxiv, 2026: 2026.07. 06.736759.
- [2]. Beeton C, et al. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Molecular pharmacology. 2005 Apr;67(4):1369-81.
- [3]. Capera J, et al. Kv1.3 Controls Mitochondrial Dynamics during Cell Cycle Progression. Cancers. 2021 Sep 04;13(17):4457.
- [4]. Admasu TD, et al. A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans. Geroscience. 2022 Apr;44(2):1029-1046.
- [5]. Colomer Molera M. Biophysics of Kv1. 3/Kv1. 5 channel interactions with regulatory KCNE1/KCNE4 subunits[J]. 2025.
