728944-69-2
728944-69-2
Chemical Structure
Vinyl-L-NIO hydrochloride
Synonym(s): L-VNIO hydrochloride
- CAS No.: 728944-69-2
- Formula:C9H17N3O2.xHCl
- Molecular Weight:N/A
SMILES: N[C@@H](CCCNC(CC=C)=N)C(O)=O.Cl.[x]
Biological Activity: Vinyl-L-NIO (L-VNIO) hydrochloride is a neuronal nitric oxide synthase (NOS) inhibitor with a rat Ki of 0.10 μM. Vinyl-L-NIO hydrochloride inhibits NADPH oxidase activity, attenuates renal fibrosis, inflammation, oxidative stress indices, and albuminuria. Vinyl-L-NIO hydrochloride can be used for the research of parkinson's disease, migraine headache, and hypertension[1][2][3][4].
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Vinyl-L-NIO hydrochloride | Vinyl-L-NIO (L-VNIO) hydrochloride is a neuronal nitric oxide synthase (NOS) inhibitor with a rat Ki of 0.10 μM. Vinyl-L-NIO hydrochloride inhibits NADPH oxidase activity, attenuates renal fibrosis, inflammation, oxidative stress indices, and albuminuria. Vinyl-L-NIO hydrochloride can be used for the research of parkinson's disease, migraine headache, and hypertension. | |||||||||||||||||||||
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References
- [1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [Content Brief]
- [2]. Yamaleyeva LM, et al. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012;59(6):529-538. [Content Brief]
- [3]. Hatanaka Y, et al. Neuronal nitric-oxide synthase inhibition facilitates adrenergic neurotransmission in rat mesenteric resistance arteries. J Pharmacol Exp Ther. 2006;316(2):490-497. [Content Brief]
- [4]. Ashley EA, et al. Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes. Circulation. 2002;105(25):3011-3016. [Content Brief]
Keywords
