744260-15-9
744260-15-9
Chemical Structure
NSD-IN-3
- CAS No.: 744260-15-9
- Formula:C13H12BrN5O
- Molecular Weight:334.17
InChIKey: KEUZGQNTDMYNJZ-UHFFFAOYSA-N
SMILES: NC1=C2C(N(CCOC3=CC=C(Br)C=C3)C=N2)=NC=N1
Biological Activity: NSD-IN-3 (compound 3) is a potent nuclear receptor binding SET domain (NSD) inhibitor. NSD-IN-3 inhibits NSD2-SET and NSD3-SET with IC50 values of 0.81 μM and 0.84 μM, respectively. NSD-IN-3 inhibits histone H3K36 dimethylation and decreases the expression of NSDs-targeted genes in non-small cell lung cancer cells. NSD-IN-3 induces s-phase cell cycle arrest and apoptosis[1].
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NSD-IN-3 | 98.0% | NSD-IN-3 (compound 3) is a potent nuclear receptor binding SET domain (NSD) inhibitor. NSD-IN-3 inhibits NSD2-SET and NSD3-SET with IC50 values of 0.81 μM and 0.84 μM, respectively. NSD-IN-3 inhibits histone H3K36 dimethylation and decreases the expression of NSDs-targeted genes in non-small cell lung cancer cells. NSD-IN-3 induces s-phase cell cycle arrest and apoptosis. | ||||||||||||||||||||
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