W2476
W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1). W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model.
For research use only. We do not sell to patients.
- CAS No.: 432016-77-8
- Formula: C15H15N5O2
- Molecular Weight:297.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 432016-77-8
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Molecular Weight 297.31
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Formula C15H15N5O2
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SMILES
O=C(C)C1=CC=C(C=C1)OCCN2C=NC3=C2N=CN=C3N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Li, T., et al., (2017). W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica, 38(7), 1024-1037. [Content Brief]
[2]. Zhong, L., et al., (2021). W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319. Chemical biology & drug design, 97(5), 1089-1099. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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