74578-38-4
74578-38-4
Chemical Structure
Tegafur-Uracil
Synonym(s): UFT; BMS-200604
- No. CAS: 74578-38-4
- Formula:C12H13FN4O5
- Molecular Weight:312.25
IUPAC Name: 5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione compound with pyrimidine-2,4(1H,3H)-dione (1:1)
InChIKey: DHMYGZIEILLVNR-UHFFFAOYSA-N
SMILES: O=C1C=CNC(N1)=O.O=C2NC(N(C3OCCC3)C=C2F)=O
Biological Activity: Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors[1][2].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Tegafur-Uracil | 99.77% | Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-1545562′,3′-Dideoxy-5-fluorouridine -
Similarity Score 0.65
HY-101748Tegadifur -
Similarity Score 0.63
HY-B0097RFloxuridine (Standard) -
Similarity Score 0.61
HY-16441Tegafur-gimeracil-oteracil potassium -
Similarity Score 0.60
HY-W587905Lamivudine impurity 9 -
Similarity Score 0.60
HY-1526303’-Deoxy-5-fluorouridine -
Similarity Score 0.59
HY-1545572′,3′-Didehydro-2′,3′-dideoxy-5-fluorouridine -
Similarity Score 0.59
HY-B0021Doxifluridine -
Similarity Score 0.58
HY-107856R5-Fluorouridine (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Casado E, et al. UFT (tegafur-uracil) in rectal cancer. Ann Oncol. 2008;19(8):1371-1378. [Content Brief]
- [2]. Ryoji Katoh, et al. Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models. Cell Mol Immunol. 2007 Aug;4(4):295-9. [Content Brief]
