766-11-0
766-11-0
Chemical Structure
5-Bromo-2-fluoropyridine
- CAS No.: 766-11-0
- Formula:C5H3BrFN
- Molecular Weight:175.99
IUPAC Name: 5-bromo-2-fluoropyridine
InChIKey: MYUQKYGWKHTRPG-UHFFFAOYSA-N
SMILES: FC1=NC=C(Br)C=C1
Biological Activity: 5-Bromo-2-fluoropyridine is a halogenated pyridine precursor. 5-Bromo-2-fluoropyridine participates in Li-Br exchange to generate a pyridyl zinc halide for Negishi cross-coupling in the synthesis of nicotinic acetylcholine receptor agonist analogues[1][2].
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5-Bromo-2-fluoropyridine | 99.60% | 5-Bromo-2-fluoropyridine is a halogenated pyridine precursor. 5-Bromo-2-fluoropyridine participates in Li-Br exchange to generate a pyridyl zinc halide for Negishi cross-coupling in the synthesis of nicotinic acetylcholine receptor agonist analogues. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-327424-Bromo-2-fluoropyridine -
Similarity Score 0.88
HY-327482-Bromo-5-fluoropyridine -
Similarity Score 0.85
HY-W0075312-Fluoro-5-iodopyridine -
Similarity Score 0.85
HY-652545-Amino-2-fluoropyridine -
Similarity Score 0.85
HY-W0026685-Bromo-2-iodopyridine -
Similarity Score 0.85
HY-W0027675-Bromo-2-chloropyridine -
Similarity Score 0.81
HY-W0036012-Bromo-4-fluoropyridine -
Similarity Score 0.81
HY-W007647R5-Bromopicolinonitrile (Standard) -
Similarity Score 0.80
HY-W0081375-Bromo-2-fluoropyrimidine -
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References
- [1]. Sutherland A, et al. Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165. The Journal of organic chemistry. 2003 Mar 21;68(6):2475-8.
- [2]. Finger G C, et al. Aromatic fluorine compounds. XI. Replacement of chlorine by fluorine in halopyridines[J]. The Journal of Organic Chemistry, 1963, 28(6): 1666-1668.
