76735-58-5
Chemical Structure
Cannflavin B
Synonym(s): Canniflavone
- CAS. Nr.: 76735-58-5
- Formula:C21H20O6
- Molecular Weight:368.38
IUPAC Name: 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChIKey: IXCUTZUASDSIJO-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC(OC)=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
Biological Activity: Cannflavin B is a flavonoid compound that can be isolated from Cannabis sativa L. Cannflavin B is inhibitors of PGE2 release (IC50: 0.7 μM), mPGES-1 (IC50: 3.7 μM), and 5-lipoxygenase. Cannflavin B has multiple activities such as anti-inflammatory, antioxidant, anti-glycation, anti-ferroptosis, anti-tumor, and anti-Leishmania (IC50: 14 μM). Cannflavin B can also inhibit the TrkB-BDNF signaling pathway[1][2][3][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Cannflavin B | 98.14% | Cannflavin B is a flavonoid compound that can be isolated from Cannabis sativa L. Cannflavin B is inhibitors of PGE2 release (IC50: 0.7 μM), mPGES-1 (IC50: 3.7 μM), and 5-lipoxygenase. Cannflavin B has multiple activities such as anti-inflammatory, antioxidant, anti-glycation, anti-ferroptosis, anti-tumor, and anti-Leishmania (IC50: 14 μM). Cannflavin B can also inhibit the TrkB-BDNF signaling pathway. | ||||||||||||||||||||
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References
- [1]. Holborn J, et al. Interference of neuronal TrkB signaling by the cannabis-derived flavonoids cannflavins A and B. Phytomedicine Plus, 2023, 3(1): 100410.
- [2]. Li H, et al. Cannflavins A and B with Anti-Ferroptosis, Anti-Glycation, and Antioxidant Activities Protect Human Keratinocytes in a Cell Death Model with Erastin and Reactive Carbonyl Species. Nutrients. 2023 Oct 27;15(21):4565. [Content Brief]
- [3]. Cannflavin B is a prenylated flavone, which can be isolated from Cannabis sativa L. Cannflavin B has anti-inflammatory activity[1]. [Content Brief]
- [4]. Tomko A. CANNFLAVINS A AND B EXERT ANTI-CANCER EFFECTS IN CHEMOTHERAPEUTIC RESISTANT BREAST CANCER CELL LINES. Dalhousie University, 2022.
