77006-29-2
Chemical Structure
4-Methylhomoibotenic acid
Synonym(s): Me-HIBO
- CAS. Nr.: 77006-29-2
- Formula:C7H10N2O4
- Molecular Weight:186.17
InChIKey: QQKCZEULAPHDJP-UHFFFAOYSA-N
SMILES: O=C(C(CC(ON1)=C(C)C1=O)N)O
Biological Activity: 4‑Methylhomoibotenic acid (Me-HIBO) is a derivative of Homoibotenic acid. 4‑Methylhomoibotenic acid is an AMPA receptor agonist that activates central excitatory amino acid receptors. 4-Methylhomoibotenic acid inhibits calcium-dependent glutamate binding with an IC50 of 0.18 μM. 4-Methylhomoibotenic acid inhibits [3H]AMPA and calcium chloride-dependent [3H]Glu binding in rat brain membranes. 4‑Methylhomoibotenic acid weakly agonizes mGluR4a and mGluR7a, reduces Forskolin (HY-15371)-stimulated cAMP accumulation, and activates metabotropic glutamate receptors coupled to phosphoinositide hydrolysis. 4‑Methylhomoibotenic acid activates evoked phosphoinositide hydrolysis in rat brain cortical slices. 4‑Methylhomoibotenic acid can be used in metabolism-related research and can also serve as an intermediate in organic synthesis-related research[1][2][3][4].
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4-Methylhomoibotenic acid | 4‑Methylhomoibotenic acid (Me-HIBO) is a derivative of Homoibotenic acid. 4‑Methylhomoibotenic acid is an AMPA receptor agonist that activates central excitatory amino acid receptors. 4-Methylhomoibotenic acid inhibits calcium-dependent glutamate binding with an IC50 of 0.18 μM. 4-Methylhomoibotenic acid inhibits [3H]AMPA and calcium chloride-dependent [3H]Glu binding in rat brain membranes. 4‑Methylhomoibotenic acid weakly agonizes mGluR4a and mGluR7a, reduces Forskolin (HY-15371)-stimulated cAMP accumulation, and activates metabotropic glutamate receptors coupled to phosphoinositide hydrolysis. 4‑Methylhomoibotenic acid activates evoked phosphoinositide hydrolysis in rat brain cortical slices. 4‑Methylhomoibotenic acid can be used in metabolism-related research and can also serve as an intermediate in organic synthesis-related research. | |||||||||||||||||||||
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References
- [1]. Christensen IT, et al. Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid. Journal of medicinal chemistry. 1992 Sep 18;35(19):3512-9.
- [2]. Stensbøl TB, et al. The AMPA receptor binding site: focus on agonists and competitive antagonists. Current pharmaceutical design. 2002;8(10):857-72.
- [3]. Honoré T, et al. The Binding of [3H]AMPA, a Structural Analogue of Glutamic Acid, to Rat Brain Membranes. Journal of Neurochemistry, 1982, 38(1): 173-178.
- [4]. Chung D S, et al. 4-Methylhomoibotenic Acid Activates a Novel Metabotropic Glutamate Receptor Coupled to Phosphoinositide Hydrolysis. The Journal of Pharmacology and Experimental Therapeutics, 1997, 283(2): 742–749.
